Effect of vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana: a secondary analysis from the ObaapaVitA trial
Identifieur interne : 000732 ( Main/Exploration ); précédent : 000731; suivant : 000733Effect of vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana: a secondary analysis from the ObaapaVitA trial
Auteurs : Lisa Hurt ; Augustinus Ten Asbroek [Pays-Bas] ; Seeba Amenga-Etego [Ghana] ; Charles Zandoh [Ghana] ; Samuel Danso [Ghana] ; Karen Edmond [Australie] ; Chris Hurt ; Charlotte Tawiah [Ghana] ; Zelee Hill ; Justin Fenty ; Seth Owusu-Agyei [Ghana] ; Oona M. Campbell ; Betty R. KirkwoodSource :
- Bulletin of the World Health Organization [ 0042-9686 ] ; 2012.
Abstract
To determine the effect of weekly low-dose vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana.
A cluster-randomized, triple-blind, placebo-controlled trial was conducted in seven districts of the Brong Ahafo region of Ghana. Women aged 15–45 years who were capable of giving informed consent and intended to live in the trial area for at least 3 months were enrolled and randomly assigned, according to their cluster of residence, to receive oral vitamin A (7500 μg) or placebo once a week. Randomization was blocked, with two clusters in each fieldwork area allocated to vitamin A and two to placebo. Every 4 weeks, fieldworkers distributed capsules and collected data during home visits. Verbal autopsies were conducted by field supervisors and reviewed by physicians, who assigned a cause of death. Cause-specific mortality rates in both arms were compared by means of random-effects Poisson regression models to allow for the cluster randomization. Analysis was by intention-to-treat, based on cluster of residence, with women eligible for inclusion once they had consistently received the supplement or placebo capsules for 6 months.
The analysis was based on 581 870 woman–years and 2624 deaths. Cause-specific mortality rates were found to be similar in the two study arms.
Low-dose vitamin A supplements administered weekly are of no benefit in programmes to reduce mortality in women of childbearing age.
Url:
DOI: 10.2471/BLT.11.100412
PubMed: 23397347
PubMed Central: 3537244
Affiliations:
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code="nlm country">England</wicri:noCountry></affiliation></author><author><name sortKey="Ten Asbroek, Augustinus" sort="Ten Asbroek, Augustinus" uniqKey="Ten Asbroek A" first="Augustinus" last="Ten Asbroek">Augustinus Ten Asbroek</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Public Health, Academic Medical Centre, Amsterdam,<country>Netherlands</country>.</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amenga Etego, Seeba" sort="Amenga Etego, Seeba" uniqKey="Amenga Etego S" first="Seeba" last="Amenga-Etego">Seeba Amenga-Etego</name><affiliation wicri:level="1"><nlm:aff id="aff3">Kintampo Health Research Centre, Ministry of Health, Kintampo,<country>Ghana</country>.</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zandoh, Charles" sort="Zandoh, Charles" uniqKey="Zandoh C" first="Charles" last="Zandoh">Charles Zandoh</name><affiliation wicri:level="1"><nlm:aff id="aff3">Kintampo Health Research Centre, Ministry of Health, Kintampo,<country>Ghana</country>.</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Danso, Samuel" sort="Danso, Samuel" uniqKey="Danso S" first="Samuel" last="Danso">Samuel Danso</name><affiliation wicri:level="1"><nlm:aff id="aff3">Kintampo Health Research Centre, Ministry of Health, Kintampo,<country>Ghana</country>.</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Edmond, Karen" sort="Edmond, Karen" uniqKey="Edmond K" first="Karen" last="Edmond">Karen Edmond</name><affiliation wicri:level="1"><nlm:aff id="aff4">School of Paediatrics and Child Health, University of Western Australia, Perth,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hurt, Chris" sort="Hurt, Chris" uniqKey="Hurt C" first="Chris" last="Hurt">Chris Hurt</name><affiliation><nlm:aff id="aff5">Wales Cancer Trials Unit, Cardiff University, Cardiff,<country>Wales</country>.</nlm:aff><wicri:noCountry code="nlm country">Wales</wicri:noCountry></affiliation></author><author><name sortKey="Tawiah, Charlotte" sort="Tawiah, Charlotte" uniqKey="Tawiah C" first="Charlotte" last="Tawiah">Charlotte Tawiah</name><affiliation wicri:level="1"><nlm:aff id="aff3">Kintampo Health Research Centre, Ministry of Health, Kintampo,<country>Ghana</country>.</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hill, Zelee" sort="Hill, Zelee" uniqKey="Hill Z" first="Zelee" last="Hill">Zelee Hill</name><affiliation><nlm:aff id="aff6">Institute of Child Health, University College London, London,<country>England</country>.</nlm:aff><wicri:noCountry code="nlm country">England</wicri:noCountry></affiliation></author><author><name sortKey="Fenty, Justin" sort="Fenty, Justin" uniqKey="Fenty J" first="Justin" last="Fenty">Justin Fenty</name><affiliation><nlm:aff id="aff7">Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London,<country>England</country>.</nlm:aff><wicri:noCountry code="nlm country">England</wicri:noCountry></affiliation></author><author><name sortKey="Owusu Agyei, Seth" sort="Owusu Agyei, Seth" uniqKey="Owusu Agyei S" first="Seth" last="Owusu-Agyei">Seth Owusu-Agyei</name><affiliation wicri:level="1"><nlm:aff id="aff3">Kintampo Health Research Centre, Ministry of Health, Kintampo,<country>Ghana</country>.</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Oona M" sort="Campbell, Oona M" uniqKey="Campbell O" first="Oona M" last="Campbell">Oona M. Campbell</name><affiliation><nlm:aff id="aff1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT,<country>England</country>.</nlm:aff><wicri:noCountry code="nlm country">England</wicri:noCountry></affiliation></author><author><name sortKey="Kirkwood, Betty R" sort="Kirkwood, Betty R" uniqKey="Kirkwood B" first="Betty R" last="Kirkwood">Betty R. Kirkwood</name><affiliation><nlm:aff id="aff1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT,<country>England</country>.</nlm:aff><wicri:noCountry code="nlm country">England</wicri:noCountry></affiliation></author></analytic><series><title level="j">Bulletin of the World Health Organization</title><idno type="ISSN">0042-9686</idno><idno type="eISSN">1564-0604</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec><title>Objective</title><p>To determine the effect of weekly low-dose vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana.</p></sec><sec><title>Methods</title><p>A cluster-randomized, triple-blind, placebo-controlled trial was conducted in seven districts of the Brong Ahafo region of Ghana. Women aged 15–45 years who were capable of giving informed consent and intended to live in the trial area for at least 3 months were enrolled and randomly assigned, according to their cluster of residence, to receive oral vitamin A (7500 μg) or placebo once a week. Randomization was blocked, with two clusters in each fieldwork area allocated to vitamin A and two to placebo. Every 4 weeks, fieldworkers distributed capsules and collected data during home visits. Verbal autopsies were conducted by field supervisors and reviewed by physicians, who assigned a cause of death. Cause-specific mortality rates in both arms were compared by means of random-effects Poisson regression models to allow for the cluster randomization. Analysis was by intention-to-treat, based on cluster of residence, with women eligible for inclusion once they had consistently received the supplement or placebo capsules for 6 months.</p></sec><sec><title>Findings</title><p>The analysis was based on 581 870 woman–years and 2624 deaths. Cause-specific mortality rates were found to be similar in the two study arms.</p></sec><sec><title>Conclusion</title><p>Low-dose vitamin A supplements administered weekly are of no benefit in programmes to reduce mortality in women of childbearing age.</p></sec></div></front></TEI><affiliations><list><country><li>Australie</li><li>Ghana</li><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Campbell, Oona M" sort="Campbell, Oona M" uniqKey="Campbell O" first="Oona M" last="Campbell">Oona M. Campbell</name><name sortKey="Fenty, Justin" sort="Fenty, Justin" uniqKey="Fenty J" first="Justin" last="Fenty">Justin Fenty</name><name sortKey="Hill, Zelee" sort="Hill, Zelee" uniqKey="Hill Z" first="Zelee" last="Hill">Zelee Hill</name><name sortKey="Hurt, Chris" sort="Hurt, Chris" uniqKey="Hurt C" first="Chris" last="Hurt">Chris Hurt</name><name sortKey="Hurt, Lisa" sort="Hurt, Lisa" uniqKey="Hurt L" first="Lisa" last="Hurt">Lisa Hurt</name><name sortKey="Kirkwood, Betty R" sort="Kirkwood, Betty R" uniqKey="Kirkwood B" first="Betty R" last="Kirkwood">Betty R. Kirkwood</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Ten Asbroek, Augustinus" sort="Ten Asbroek, Augustinus" uniqKey="Ten Asbroek A" first="Augustinus" last="Ten Asbroek">Augustinus Ten Asbroek</name></noRegion></country><country name="Ghana"><noRegion><name sortKey="Amenga Etego, Seeba" sort="Amenga Etego, Seeba" uniqKey="Amenga Etego S" first="Seeba" last="Amenga-Etego">Seeba Amenga-Etego</name></noRegion><name sortKey="Danso, Samuel" sort="Danso, Samuel" uniqKey="Danso S" first="Samuel" last="Danso">Samuel Danso</name><name sortKey="Owusu Agyei, Seth" sort="Owusu Agyei, Seth" uniqKey="Owusu Agyei S" first="Seth" last="Owusu-Agyei">Seth Owusu-Agyei</name><name sortKey="Tawiah, Charlotte" sort="Tawiah, Charlotte" uniqKey="Tawiah C" first="Charlotte" last="Tawiah">Charlotte Tawiah</name><name sortKey="Zandoh, Charles" sort="Zandoh, Charles" uniqKey="Zandoh C" first="Charles" last="Zandoh">Charles Zandoh</name></country><country name="Australie"><noRegion><name sortKey="Edmond, Karen" sort="Edmond, Karen" uniqKey="Edmond K" first="Karen" last="Edmond">Karen Edmond</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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